bellini duct carcinoma pathology outlines
We report the case of a 62-year old … Collecting duct carcinoma (CDC) is a type of kidney cancer that originates in the duct of Bellini of the kidney and also known by several synonyms like Bellini duct carcinoma, medullary renal carcinoma, distal renal tubular carcinoma and distal nephron carcinoma[1, 2].CDC is an unusual variant of renal cell carcinoma and accounts for about 1% of all renal cell carcinomas. It arises from the distal nephron, more specifically from the collecting duct. "Extrahepatic bile duct carcinoma with extensive intraepithelial spread: a clinicopathological study of 21 cases.". .style1 {font-family: Arial, Helvetica, sans-serif} Metastases t o regional lymph nodes, l ungs, adrenal glands and liver may be present at presentation. Mod Pathol 21 (7): 807-16. doi : 10.1038/modpathol.2008.65 . ... 0 slides . Case Presentation. Surgical Pathology Criteria Jabbour R, Maddah J, Makhoul R, Mokbel E, Nasr F. We report two rare cases of Bellini duct carcinoma, a rare variant of renal cell carcinoma.CASE 1: The patient, a 73-year-old female, was admitted to the hospital for macroscopic hematuria and right flank pain. Hum Pathol. Its morphological features are extremely variable, making its diagnosis difficult. Ductal Carcinoma-in-situ 10 slides. It was previously subgrouped with the RCCs by the World Health Organization (WHO) in 1981 with the alternative name "Bellini duct carcinoma," but has since been recognized as a separate entity. Malignant includes: DCIS, LCIS, ductal carcinoma (DC) and lobular carcinoma (LC), some papillary lesions. Bellini duct carcinoma of the kidney. ICD-10 online (WHO-Version 2019) Das Ductus-Bellini-Karzinom ist eine sehr seltene Form eines Nierenzellkarzinoms, die von den Sammelrohren ( lateinisch Tubulus renalis colligens, Ductus Bellini) ausgeht. Elwood H, Chaux A, Schultz L, Illei PB, Baydar DE, Billis A, Sharma R, Argani P, Epstein JI, Netto GJ. Adenoma. Carcinoma of the collecting ducts of Bellini and renal medullary carcinoma are rare aggressive neoplasms of putative distal nephron origin. Mean tumor size was 94 mm. J Urol. (range 30 to 150). 1998 Feb;15(1):54-67. Collecting (Bellini) duct carcinoma (CDC) or Bellini duct carcinoma (BDC) is a rare subtype of kidney tumors, accounting for less than 3% and known to have the worst prognosis. document.write('' + emailE + '') Bellini duct carcinoma is a very rare type of renal cell carcinoma (RCC), accounting for less than 1%. En tomodensitométrie (Figures 1 et 2), le carcinome de Be… Here, we present the case of a 65-year-old Japanese patient with a renal cell carcinoma arising from Bellini duct epithelial cells. Collecting duct renal cell carcinoma: a matched analysis of 41 cases. Bellini duct carcinomas have recently been identified as a new entity in the spectrum of renal cell carcinomas and 10 cases have now been reported. emailE=('rouse' + '@' + 'stan' + 'ford.edu') Renal collecting (Bellini) duct carcinoma displays similar characteristics to upper tract urothelial cell carcinoma. Renal collecting (Bellini) duct carcinoma displays similar characteristics to upper tract urothelial cell carcinoma. Bellini Duct Carcinoma (BDC) or collecting duct carcinoma is a rare but very aggressive renal neoplasm which originates from the epithelium of the ducts of Bellini in the distal tubule. The coexistence of two synchronous neoplasms in the same kidney is highly infrequent. Stanford CA 94305-5342, Original posting/last update: 1/24/11, 11/2/16, Metastatic adenocarcinoma must be ruled out clinically and by immunohistochemistry when possible, In the older pathology literature, collecting duct carcinoma was sometimes referred to as Bellini duct carcinoma, reflecting its presumed site of origin. Collecting duct carcinoma is positive for pancytokeratins (AE1/AE3) and high-molecular-weight cytokeratin, EMA, vimentin, and Ulex europaeus lectin (Table 9).PAX2 and PAX8 (more specific than PAX2) may be positive, as well. Srigley JR, Eble JN. The patient currently remains disease-free. Nucleoli are conspicuous and eosinophilic at 400x and visible but not prominent at 100x. Carcinoma. Bellini duct carcinoma of kidney derives from collecting duct and is associated with an aggressive course and extremely poor prognosis. A renal cancer with intermediate characteristics between collecting (Bellini) duct carcinoma and urothelial carcinoma: case report and review of the literature. Metastatic adenocarcinoma must be ruled out in every case. Bellini duct carcinoma: two case reports. Though generally symptomatic, the aggressive nature of most of these tumours is such that more than 50% of patients have metastatic disease at the time of initial diagnosis. 2008 Jun;21(6):647-52. Human epithelial cells of the kidney present a wide spectrum of cytological and histological variation. Commonly associated with invasive carcinoma. Breast Carcinomas. Urology. emailE=('john.higgins' + '@' + 'stan' + 'ford.edu') It is the most common type of breast cancer (70 - 80 %). Less commonly associated with invasive carcinoma. Maestroni U(1), Ferretti S, Dinale F, Froio E, Pilato FP, Ciuffreda M, Mellissari M, Cortellini P. Most patients with CDC have distant metastasis at the time of the initial diagnosis [2]. Pathology and genetics of tumors of the Urinary System and Male Genital Organs, 4th edition,. 2010 Jul;34(7):965-9. Natsume O(1), Ozono S, Futami T, Ohta M. Author information: (1)Department of Urology, Nara National Hospital, Japan. It has been shown that patients may have better survival when treated with a chemotherapy regimen used … Grade 2. Collecting (Bellini) duct carcinoma (CDC) is a highly malignant and rare kidney tumor. We report a rare case of Bellini duct carcinoma, which is an unusual variant of renal cell carcinoma. Generally, Bellini duct carcinoma has a poor prognosis. Collecting duct carcinoma should be considered a diagnosis of exclusion; Firm mass centered on the renal medulla. Mod Pathol. -->, Prominent eosinophilic nucleoli Purpose: We describe diagnostic and therapeutic characteristics, and long-term followup of collecting (Bellini) duct carcinoma. February 2016 Papillary Carcinoma … Digital Atlas of Breast Pathology ; Pathology Outlines - Breast Nonmalignant ; Pathology Outlines - Breast Malignant ... Lobular carcinoma (a pitfall) may appear to be a stromal problem, i.e. Mod Pathol 21 (7): 807-16. doi : 10.1038/modpathol.2008.65 . PAX8 (+)/p63 (-) immunostaining pattern in renal collecting duct carcinoma (CDC): a useful immunoprofile in the differential diagnosis of CDC versus urothelial carcinoma of upper urinary tract. Collecting duct carcinoma of kidney. We report our 12-year experience with CDC and the results of a retrospective analysis of patients and tumor characteristics, clinical manifestations, and imaging features by computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET)/CT. with a clear perinucleolar halo, High grade renal adenocarcinoma arising in medulla of the kidney, with a predominantly invasive tubular growth pattern, Clearly overlaps morphologically and immunophenotypically with, Metastatic adenocarcinoma must be ruled out in every case, Mucinous tubular and spindle cell carcinoma, Mucinous tubular and spindle cell carcinoma, Mucinous Tubular and Spindle Cell Carcinoma of the Kidney, Clear cell (conventional) renal cell carcinoma, Multilocular renal cell neoplasm of low malignant potential, Hereditary leiomyomatosis associated renal cell carcinoma, Neuroblastoma associated renal cell carcinoma, Renal cell carcinoma associated with end stage renal disease, Succinate dehydrogenase-deficient renal cell carcinoma, Thyroid-like follicular carcinoma of the kidney, Clear cell papillary renal cell carcinoma, Oncocytic papillary renal cell carcinoma, CD10, AMACR/Racemase, PN15/gp200 positive, CD10, AMACR/Racemase, PN15/gp200 negative, Adjacent usual urothelial carcinoma or carcinoma in situ frequently present, May show areas of squamous differentiation, Associated with sickle cell trait/disease, Prominent invasion and desmoplastic stroma, Nucleoli are absent or inconspicuous and basophilic at 400x magnification, Nucleoli are conspicuous and eosinophilic at 400x and visible but not prominent at 100x, Nucleoli are conspicuous and eosinophilic at 100x, Extreme nuclear pleomorphism, multinucleate giant cells, and/or rhabdoid and/or sarcomatoid differentiation. [1][2][3], Synonyme sind: Sammelgangkarzinom; Sammelrohrkarzinom; DBK; Ductus-Bellini-Karzinom. Collecting duct carcinoma (CDC) of the kidney, also known as Bellini tumor, is a rare kidney neoplasm, accounting for about 1–2% of the total of epithelial kidney tumors. Collecting duct carcinoma is an aggressive malignancy derived from the renal medulla, whereas most renal cell carcinomas arise from the convoluted tubules of the cortex [1,2,3,4]. Lectin histochemistry demonstrated positive staining with soyabean agglutinin and peanut agglutinin. Semin Diagn Pathol. Lobular carcinoma (a pitfall) may appear to be a stromal problem, i.e. It is known to have multiple clinical presentations; this is why it can be easily misdiagnosed. Carcinoma of Bellini is an uncommon tumor type arising from the collecting duct cells and accounts for 0.5%-2% of all renal tumors. Background . J Urol 2006; 176:40. //--> Collecting duct carcinoma of the kidney: an immunohistochemical evaluation of the use of antibodies for differential diagnosis. Orsola A, Trias I, Raventós CX, et al. Collecting duct carcinoma, also known as Bellini duct carcinoma is a rare renal tumour of high malignancy. Nucleoli are conspicuous and eosinophilic at 100x. Srigley JR, Delahunt B. Author information: (1)Department of Urology, Clínica Plató, Barcelona, Spain. This tumour often occurs in a young population and has a bad prognosis. annaorsola@hotmail.com A l'échographie, il n'existe pas de caractéristique tumorale particulière. Bellini duct carcinoma: a case report. Renal medullary carcinoma: rhabdoid features and the absence of INI1 expression as markers of aggressive behavior. Visual survey of surgical pathology with 11065 high-quality images of benign and ... Blunt Duct Adenosis (Columnar Cell Change) 5 slides. Main duct type. It is rare, accounting for 1-3% of all kidney cancers. Behaviour. rare renal tumors – bellini duct carcinoma andrzej kierstan 1 , Marek sosnowski 1 , radosław Minias 2 , Zbigniew Jabłonowski 1 1 1 st Department of Urology, Medical University of Łódź, Poland The patient underwent left open radical nephrectomy with IVC thrombectomy … We present a rare clinical case of renal cell carcinoma from the collection tubules-carcinoma of Bellini. Histomorphological differentiation from the more common renal cell carcinoma of the proximal tubuli is difficult. [1] Although some cases had been reported earlier, [2] it was not recognized as a distinct clinicopathologic entity until 1986 when Lewi and Fleming [3] determined the Uncommon and recently described renal carcinomas. Although renal carcinoma can involve any type of renal cell, the most common is renal cell carcinoma of the proximal tubuli. Tokuda N, Naito S, Matsuzaki O, Nagashima Y, Ozono S, Igarashi T; Japanese Society of Renal Cancer. Orsola A, Trias I, Raventós CX, et al. It is known to originate in the distal part of the collecting duct (1), and has a very dismal prognosis, with short survival and … 1997 Sep;50(7):798-9. Immunohistochemical analysis of SMARCB1/INI-1 expression in collecting duct carcinoma. Pathology and genetics of tumors of the Urinary System and Male Genital Organs, 4th edition,. Collecting duct carcinoma is positive for pancytokeratins (AE1/AE3) and high-molecular-weight cytokeratin, EMA, vimentin, and Ulex europaeus lectin (Table 9).PAX2 and PAX8 (more specific than PAX2) may be positive, as well. As a result, it is hardly surprising that there are no references to renal cell carcinoma (RCC) combined with CDC of the same kidney in the literature.
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