prognostic marker for oral squamous cell carcinoma

prognostic marker for oral squamous cell carcinoma

FOIA This distinguishing marker can help in improving therapeutic options in patients diagnosed with oral verrucous carcinoma. Cortactin is a prognostic marker for oral squamous cell carcinoma and its overexpression is involved in oral carcinogenesis. Prognostic and predictive markers for perineural and bone invasion of oral squamous cell carcinoma Jaroslav Michalek a , Svetlana Brychtova a , Richard Pink b , Zdenek Dvorak c a Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech Republic ( a )…, National Library of Medicine Int J Oral Sci 2013; 5: 59–65. The present study suggests that LRP6 could be a potential biomarker for OSCC patients, and might further assist in the therapeutic decisions in OSCC treatment. It has been concluded that a large number of molecular markers are associated with occurrence, progression, and prognosis of squamous cell carcinoma. In general, patients diagnosed with small tumors have a fairly good prognosis, but some small tumors have an aggressive behavior leading to early death. A) GLUT1 membrane immunostaining in oral squamous cell carcinoma, 400×; B) GLUT1 expression in oral squamous cell carcinoma. There was no association between marker expression and radioresistance or disease-specific survival. Plectin as a prognostic marker in non-metastatic oral squamous cell carsinoma. Macrophage migration inhibitory factor (MIF) is considered a pro-tumour factor. 2020 Feb 25;10:212. doi: 10.3389/fonc.2020.00212. Oddveig G. Rikardsen, Synnøve Magnussen, Gunbjørg Svineng, Elin Hadler-Olsen, Lars Uhlin-Hansen, Sonja E. Steigen (submitted) IV. In oral squamous cell carcinoma (OSCC), TMEs have been associated with prognosis of cancer patients and are evaluated by microscopy; however, these methods of evaluation vary among studies. Eligible studies were identified through a literature search of MEDLINE/PubMed until January 2016. Identifying informative prognostic biomarkers for oral tongue squamous cell carcinoma (OTSCC) is of great importance in order to better predict tumour behaviour and … In this study, matrix-assisted laser desorption ionization imaging mass spectrometry (MALDI-IMS)-based proteomic strategy was used to profile the differentially expressed peptides/proteins between OSCC tissues and their adjacent noncancerous tissues. Author information: (1)Department of Oral Pathology and Oral Radiology, Institute of Dentistry, Faculty of Medicine, University of Turku, Turku, Finland. ( a ) Schematic illustration of…, LRP6 upregulation is correlated with OSCC development. 8600 Rockville Pike Oral squamous cell carcinoma (OSCC) is a leading cause of cancer-related deaths worldwide, with 500 000 new cases each year. Oral cancer is a subset of head and neck cancers, which originates in the oral cavity [].At least 90% of oral cancers originate from squamous cells and are accordingly designated as oral squamous cell carcinoma (OSCC) [].Despite continuous advances in treatment strategies and diagnostic methods, the incidence and mortality rates associated with OSCC are increasing [3, 4]. The systemic inflammatory response and nutritional status of patients with malignant tumors are related to postoperative results. 2017 Oct;23(7):897-912. doi: 10.1111/odi.12620. Enhanced interferon signaling pathway in oral cancer revealed by quantitative proteome analysis of microdissected specimens using 16O/18O labeling and integrated two-dimensional LC-ESI-MALDI tandem MS. Silencing JARID1B suppresses oncogenicity, stemness and increases radiation sensitivity in human oral carcinoma. Epub 2015 Jul 13. The immunostaining results show over- to moderate expression of cortactin in 85% (104/122) of oral squamous cell carcinoma (OSCC) tissues and in all 15 leukoplakia tissues examined. Global cancer statistics, 2012. (, LRP6 upregulation is correlated with OSCC development. 8600 Rockville Pike In this study, we examined cortactin expression by immunohistochemistry in human oral tumors and murine tongue tumors which were induced by the carcinogen 4-nitroquinoline 1-oxide (4-NQO). Please enable it to take advantage of the complete set of features! Furthermore, we demonstrated that the expression of LRP6 in OSCC cells is positively correlated with its downstream oncogene, FGF8. Notably, knockdown of LRP6 inhibited the proliferation ability of OSCC cells. Would you like email updates of new search results? Int J Mol Sci. Oral squamous cell carcinoma (OSCC) is a major type of head and neck cancer, accounting for ~2%–4% of all incident cancer cases per year. As the morbidity and mortality of the disease have increased year by year, the search for a promising diagnostic and prognostic biomarker for the disease is becoming increasingly urgent. FGF8 induces epithelial-mesenchymal transition and promotes metastasis in oral squamous cell carcinoma. Clipboard, Search History, and several other advanced features are temporarily unavailable. Diagnostic aids for detection of oral precancerous conditions. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. Li Q, Dong H, Yang G, Song Y, Mou Y, Ni Y. Note both GLUT1 expression: membrane and nucleus (arrows), 200×; C) GLUT3 membrane immunostaining in oral squamous cell carcinoma; D) No GLUT3 immunostaining. Front Oncol. Here, we present a systematic review to identify, evaluate and summarize the evidence for OSCC reported markers. Cancer J Clin 2015; 65: 87–108. Peurala E(1), Tuominen M(1), Löyttyniemi E(2), Syrjänen S(1)(3), Rautava J(1)(3). Characterisation and prognostic value of tertiary lymphoid organs in oral squamous cell … Hsu NY, Yeh KT, Chiang IP, Pai LY, Chen CY, Ho HC. Mol Cell Proteomics. Oral This site needs JavaScript to work properly. EMS1 (chromosome eleven, band q13, mammary tumor and squamous cell carcinoma-associated gene 1) gene amplification and the concomitant cortactin overexpression have been reported to associate with poor prognosis and tumor metastasis. Lin CS, Lin YC, Adebayo BO, Wu A, Chen JH, Peng YJ, Cheng MF, Lee WH, Hsiao M, Chao TY, Yeh CT. Cancer Lett. Various immune cells have been suggested as prognostic markers for cancer patients. However, the prognostic value of TILs remains unclear in oral squamous cell carcinoma (OSCC). -, Zhou Y, Zhu X, Lu R, Dan H, Wang F, Wang J et al. This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Background: Oral squamous cell carcinoma (OSCC) is associated with a poor 5-year survival rate. Oral Oncol. Oral Dis. Accessibility Eligible studies were identified through a literature search of MEDLINE/PubMed until January 2016. LRP6 is identified as a potential prognostic marker for oral squamous cell carcinoma via MALDI-IMS In general, patients diagnosed with small tumors have a fairly good prognosis, but some small tumors have an aggressive behavior leading to early death. 2007 May;43(5):508-14. doi: 10.1016/j.oraloncology.2006.05.008. ( a ) Schematic illustration…, Altered peptide peaks identified by MALDI-IMS. Tumor markers of increased proliferation in oral carcinoma have been identified and explored for more than a decade now. Cortactin overexpression in the esophageal squamous cell carcinoma and its involvement in the carcinogenesis. Privacy, Help METHODS: Altogether, 288 patients with oral SCC were considered, as well as all platelet counts between 1 and 5 days prior to surgical treatment, recurrence rate, and lymph node metastasis. Oral squamous cell carcinoma (OSCC) is associated with a poor 5-year survival rate. The promise of stem cell markers in the diagnosis and therapy of epithelial dysplasia and oral squamous cell carcinoma. Vesicular stomatitis virus matrix protein (VSVMP) inhibits the cell growth and tumor angiogenesis in oral squamous cell carcinoma. Would you like email updates of new search results? Epub 2018 Jul 6. There are at present no reliable prognostic biomarkers for oral cancers. Among them, LRP6 expression was found to be upregulated in OSCC tissues, and correlated with a cluster of clinicopathologic parameters, including smoking, drinking, tumor differentiation status, lymph node metastasis and survival time. Sixty-seven unique peptide peaks and five distinct proteins were identified with changed expression levels. An update on the implications of cyclin D1 in oral carcinogenesis. Chi LM, Lee CW, Chang KP, Hao SP, Lee HM, Liang Y, Hsueh C, Yu CJ, Lee IN, Chang YJ, Lee SY, Yeh YM, Chang YS, Chien KY, Yu JS. Yuan Y(1), Xie X(2), Jiang Y(1), Wei Z(1), Wang P(1), Chen F(1), Li X(1), Sun C(1), Zhao H(1), Zeng X(1), Jiang L(1), Zhou Y(1), Dan H(1), Feng M(1), Liu R(1), Wang Z(1), Chen Q(1). COVID-19 is an emerging, rapidly evolving situation. Epub 2009 Mar 18. In an animal model, cortactin is shown to upregulate in infiltrating squamous cell carcinoma, papilloma, and epithelia with squamous hyperplasia, indicating that cortactin induction is an early event during oral carcinogenesis. STC2 expression was examined in 2 independent cohorts of OSCC tissues by immunohistochemistry. Methods: We evaluated the associations between tumor-infiltrating CD8 + T-cell density and survival in five distinct compartments in 139 OSCC cases. Here, we present a systematic review to identify, evaluate and summarize the evidence for OSCC reported markers. Further, statistical analysis indicates that cortactin overexpression appears to be a predictor for shorter survival and poorer prognosis in OSCC patients. Bethesda, MD 20894, Copyright Cancer J Clin 2016; 66: 7–30. Clin Cancer Res. 2018 Sep 21;18(1):911. doi: 10.1186/s12885-018-4806-7. 2018 Nov;233(11):8499-8507. doi: 10.1002/jcp.26789. National Library of Medicine Prognostic biomarkers in oral squamous cell carcinoma: A systematic review Over the years, several tumor biomarkers have been suggested to foresee the prognosis oral squamous cell carcinoma (OSCC) patients. Eosinophilia is a favorable prognostic marker for oral cavity and lip squamous cell carcinoma. In this article, we present a systematic review and meta-analysis of studies assessing the prognostic … -, Siegel RL, Miller KD, Jemal A. -, Torre LA, Bray F, Siegel RL, Ferlay J, Lortet‐Tieulent J, Jemal A. Cortactin is a prognostic marker for oral squamous cell carcinoma and its overexpression is involved in oral carcinogenesis Yu‐Ching Liu Department of Medical Research, China Medical University Hospital, Taichung, Taiwan Unable to load your collection due to an error, Unable to load your delegates due to an error, MALDI-IMS analyses of OSCC and adjacent noncancerous areas. Hao Y, Xiao Y, Liao X, Tang S, Xie X, Liu R, Chen Q. Int J Oral Sci. Epub 2018 May 24. Careers. 2019 May;25(4):949-971. doi: 10.1111/odi.12913. Ramos-García P, Gil-Montoya JA, Scully C, Ayén A, González-Ruiz L, Navarro-Triviño FJ, González-Moles MA. Haoran Ma 1*, Lijuan Li 1*, Lizhou Jia 2, Aixiu Gong 1, Aitao Wang 3, Lingli Zhang 4, Mingyan Gu 5 #, Genxiong Tang 1 # 1. FOIA POM121 is identified as a novel prognostic marker of oral squamous cell carcinoma . CONCLUSIONS: These preliminary findings strongly support the fact that Notch4 is downregulated in oral verrucous carcinoma and could be considered as a suitable prognostic marker in distinguishing oral verrucous carcinoma from oral squamous cell carcinoma. (, FGF8 is required for LRP6-induced proliferation in OSCC cell lines. Accessibility Tang XH, Knudsen B, Bemis D, Tickoo S, Gudas LJ. (, Altered peptide peaks identified by MALDI-IMS. The aim was to evaluate TATE in 83 oral cavity and 16 lip SCCs as well as the best possible use of TATE as a prognostic marker. The aim of the present study was to evaluate whether thrombocytosis can be used as a prognostic marker for oral squamous cell carcinoma (SCC). oral squamous cell carcinoma, prognostic marker, survival, tissue compartment, tumor‐infiltrating CD8+ T cells 1 carcinoma (OSCC) is associated with distinct clinical charac| INTRODUCTION The oral cavity is a distinct site in the head and neck region, and oral cavity cancers account for 3% of all cancers. Warnakulasuriya S, Jia C, Johnson N, Houghton J. p53 and Prevention and treatment information (HHS). LRP6 is identified as a potential prognostic marker for oral squamous cell carcinoma via MALDI-IMS. COVID-19 is an emerging, rapidly evolving situation. Junction plakoglobin, a potential prognostic marker of oral squamous cell carcinoma, promotes proliferation, migration and invasion Juan Fang Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Stomatological Hospital, Sun Yat‐Sen University, Guangzhou, China prognostic marker in early stage oral squamous cell carcinoma. Oral cavity and esophageal carcinogenesis modeled in carcinogen-treated mice. Mohajertehran F, Sahebkar A, Zare R, Mohtasham N. J Cell Physiol. There are at present no reliable prognostic biomarkers for oral cancers. Hallmarks of Cancer-Related Newly Prognostic Factors of Oral Squamous Cell Carcinoma. 2016 Sep 13;7(37):59987-60004. doi: 10.18632/oncotarget.11046. Liu YC(1)(2), Ho HC(3), Lee MR(3), … EMS1; carcinogenesis; cortactin; oral squamous cell carcinoma; overexpression. 2021 Mar 1;13(1):6. doi: 10.1038/s41368-021-00111-x. Therefore, HIF-1α, CA-IX, COX-2, Ki-67, and erythropoietin receptor are not suitable prognostic markers for tongue squamous cell carcinoma. (. It is suggested that cortactin expression is mediated in the progression of pre-malignancy to papilloma, based on earlier cortactin induction in pre-malignancy preceding cyclin D1 in papilloma. ( a )…, FGF8 is required for LRP6-induced proliferation in OSCC cell lines. Mouse Tumor-Bearing Models as Preclinical Study Platforms for Oral Squamous Cell Carcinoma. Cancer J Clin 2011; 61: 69–90. Cancer statistics, 2016. The overall 5-year survival rate following treatment for oral squamous cell carcinoma is around 50% in most published series. Oral Pathol Med 2012;41:559-67. (, Bioinformatics analysis of proteins identified from MALDI-IMS. Keywords: Department of Stomatology, Children's Hospital of Nanjing Medical University, Nanjing, China 2. Thus, cortactin may have an important role in the development of oral tumors in human and mice. Dis Esophagus. Prevention and treatment information (HHS). Epub 2006 Sep 26. Amplifications of TAOS1 and EMS1 genes in oral carcinogenesis: association with clinicopathological features. -. Thus, to Xie X, Jiang Y, Yuan Y, Wang P, Li X, Chen F, Sun C, Zhao H, Zeng X, Jiang L, Zhou Y, Dan H, Feng M, Liu R, Chen Q. Oncotarget. (, Expression level of LRP6 was associated with the proliferation ability of OSCC cells. Oral Dis. See this image and copyright information in PMC. Privacy, Help 2018 Aug 16;19(8):2413. doi: 10.3390/ijms19082413. 2009 Jul;8(7):1453-74. doi: 10.1074/mcp.M800460-MCP200. In conclusion, cortactin overexpression is frequently observed in human OSCC and mouse tongue tumors. Zhong L, Liu Y, Wang K, He Z, Gong Z, Zhao Z, Yang Y, Gao X, Li F, Wu H, Zhang S, Chen L. BMC Cancer. eCollection 2020. However, the mechanisms underlying OSCC development are relatively unknown. 27. Clipboard, Search History, and several other advanced features are temporarily unavailable. The objective of this study was to investigate the expression of MIF and its receptor CD74 in OSCC tissues, and to study the function of MIF in OSCC cells. MALDI imaging reveals NCOA7 as a potential biomarker in oral squamous cell carcinoma arising from oral submucous fibrosis. An update of knowledge on cortactin as a metastatic driver and potential therapeutic target in oral squamous cell carcinoma. -, Messadi DV. Over the years, several tumor biomarkers have been suggested to foresee the prognosis oral squamous cell carcinoma (OSCC) patients. ( a ) Representative images of…, Expression level of LRP6 was associated with the proliferation ability of OSCC cells.…, Expression of LRP6 is positively associated with proto-oncogenic protein FGF8. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 799-812, 2017. (, Expression of LRP6 is positively associated with proto-oncogenic protein FGF8. Epub 2017 Mar 31. ( a ) Representative hematoxylin and eosin…, Bioinformatics analysis of proteins identified…, Bioinformatics analysis of proteins identified from MALDI-IMS. MALDI-IMS analyses of OSCC and adjacent noncancerous areas. NCI CPTC Antibody Characterization Program. Oral squamous cell carcinoma (OSCC) has always been one of the most aggressive and invasive cancers among oral and maxillofacial malignancies. Oral Oncol 2012; 48: 110–116. Eosinophils are frequently encountered with squamous cell carcinomas (SCC) and it has been proposed that tumor‐associated tissue eosinophilia (TATE) could be of prognostic significance in oral SCC. We examined the usefulness of the prognostic nutritional index (PNI) as a prognostic tool in patients with oral squamous cell … Aside from tobacco and alcohol consumption, further determinants have been considered to increase the risk of OSCC development, such as micronutrient deficiencies, chronic traumatism, poor oral hygiene and viruses. OSCC is the most frequent malignant tumour of the oral cavity, accounting for more than 90% of malignant tumours of this anatomic region and it often arises from precursor lesions. The major prognostic factors are stage at the time of diagnosis, unexpected close margins at resection, depth and pattern of tissue invasion by carcinoma and extracapsular spread. 2008;21(5):402-8. doi: 10.1111/j.1442-2050.2007.00775.x. We have evaluated the prognostic value of inflammatory markers for patients with oral squamous cell carcinoma (OSCC). Over the years, several tumor biomarkers have been suggested to foresee the prognosis oral squamous cell carcinoma (OSCC) patients. Bethesda, MD 20894, Copyright carcinoma, peripheral blood mononuclear cells, prognostic marker 6736 KITAMURA et al : PROGNOSTIC FACTOR ANALYSES OF CK17 IN ORAL SQUAMOUS CELL CARCINOMA breast, colorectal and pancreatic carcinoma patients ( 8,24-26). Careers. However, the prognostic value of TILs remains unclear in oral squamous cell carcinoma (OSCC). Biomarkers: paving stones on the road towards the personalized precision medicine for oral squamous cell carcinoma. Tumorous and adjacent tissues were collected from … This study aimed to access the prognostic value of STC2 in oral squamous cell carcinoma (OSCC) and its implications in oral tumorigenesis. Unable to load your collection due to an error, Unable to load your delegates due to an error. Here, we present a systematic review to identify, evaluate and summarize the evidence for OSCC reported markers. The presence of tumor‐infiltrating lymphocytes (TILs) is associated with improved survival in head and neck squamous cell carcinoma. 2015 Nov 1;368(1):36-45. doi: 10.1016/j.canlet.2015.07.003. 2004 Jan 1;10(1 Pt 1):301-13. doi: 10.1158/1078-0432.ccr-0999-3. The authors declare no conflict of interest. Ramos-García P, González-Moles MÁ, González-Ruiz L, Ayén Á, Ruiz-Ávila I, Navarro-Triviño FJ, Gil-Montoya JA. However, its clinical relevance in oral squamous cell carcinoma (OSCC) remains unclear. Note also GLUT3 expression in the inflammatory cells, 200×. There was no correlation between marker expression and prognosis.

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