recent articles on oral squamous cell carcinoma

recent articles on oral squamous cell carcinoma

5 However, SCCOP has been increasing in incidence in recent decades as a result of chronic latent infection with the human papillomavirus and seems to disproportionately affect younger people. A vast quantity of scientific, clinical and epidemiological data shows that tobacco is associated with the development of oral squamous cell carcinoma, and its … To rationalize perspectives on preventive … Seventy‐two patients diagnosed clinically with either oral leukoplakia (OLK) or oral squamous cell carcinoma were included. 1. Gene expression-based molecular classification showed that OSCC can be divided into distinct subtypes and these have a preferential response to different types of therapies, suggesting that these classifications could have clinical implications. Oral squamous cell carcinoma is a type of cancer, that usually develops on the squamous or epithelial cells that cover the oral cavity. 1 Although new diagnosis and … Despite several diagnostic and therapeutic advances over the last decades, the rate of mortality and 5-year survival of patients with OSCC has not been improved markedly. COVID-19 is an emerging, rapidly evolving situation. Oral squamous cell carcinoma (OSCC) is the most common oral malignancy accounting for 94% of all malignant neoplasms of the oral cavity. The control of distant metastasis in oral squamous cell carcinoma is an important determinant of improved prognosis. Mutations in FAT1, CASP8, CDKN2A, and NOTCH1 are more frequently found in OSCC when compared to non-OSCC head and neck cancers and other squamous cell carcinomas, and HRAS and PIK3CA are the only significantly mutated oncogenes. We show that the combination of conductive polymer spray mass spectrometry (CPSI-MS) and machine learning provides a simple, fast, and affordable method for oral squamous cell carcinoma diagnosis with 86.7% accuracy. Four pairs of tumor and adjacent normal tissues were collected from OSCC patients, and differentially expressed genes (DEGs) were screened via high-throughput RNA sequencing (RNA-seq). For several decades the management of OSCC consisted of surgery with or without radiotherapy or chemoradiotherapy. Xie X, Wang Z, Chen F, Yuan Y, Wang J, Liu R, Chen Q. Elife. It is the second most common form of skin cancer, and up to 700 000 new cases are diagnosed each year in the United States. Chai AWY, Yee PS, Price S, Yee SM, Lee HM, Tiong VK, Gonçalves E, Behan FM, Bateson J, Gilbert J, Tan AC, McDermott U, Garnett MJ, Cheong SC. Song A, Wu Y, Chu W, Yang X, Zhu Z, Yan E, Zhang W, Zhou J, Ding X, Liu J, Zhu H, Ye J, Wu Y, Zheng Y, Song X. Int J Biol Sci. An update on the latest evidence for managing the clinically negative neck (cN0) in oral squamous cell carcinoma. Also, this article defines squamous cell carcinoma stages of progression from precancerous to malignant and the various … Epub 2015 Jun 1. Finally, this article discusses the various forms of squamous cell carcinoma and the physiological changes that occur within the skin … Methods: Gene expression was measured by qRT-PCR in tumor tissues and cell lines. 2015 Aug;236(4):505-16. doi: 10.1002/path.4550. 2016 Dec 1;383(1):106-114. doi: 10.1016/j.canlet.2016.09.014. Here, we reviewed the current findings from genomic analyses of OSCC and discuss how these studies inform on the biological mechanisms underlying OSCC. PubMed Article PubMed Central Google Scholar Background: Oral squamous cell carcinoma (OSCC) is a common oral cancer. Oral squamous cell carcinoma is predominately associated with tobacco and betel nut use. However, the pathogenesis of oral carcinoma without a known carcinogen is yet to be elucidated. Overall incidence and mortality attributed to oral squamous cell carcinoma (OSCC) is increasing, with current estimates of age-standardized incidence and mortality of 6.6/100,000 and 3.1/100,000 in men and 2.9/100,000 and 1.4/100,000 in women, respectively. Immune Escape Mechanisms and Their Clinical Relevance in Head and Neck Squamous Cell Carcinoma. In India, oral Even within one geographic location, the incidence varies among groups … Oral squamous cell carcinoma (OSCC) is an important cause of morbidity and mortality worldwide with an incidence rate that varies widely by geographic location. The gingivae, palate, retromolar area and the buccal and labial mucosa are oral sites less frequently affected [7]. However, other methods of diagnosis are technique sensitive and further exhaustive research is required. Epub 2018 Feb 28. eCollection 2021. 2021 Feb 25;14:1275-1289. doi: 10.2147/OTT.S293148. SCC of the oral tongue accounts for about half of oral cavity SCC [1]. The distribution of these mutations also differs in populations with distinct risk habits. A pure extract from the edible part and leaves of fresh artichoke was added to oral squamous carcinoma cell lines and to control group to evaluate the expression of caspase-9, Bcl-2, and Bax genes. In this review, we describe metastasis related to OSCC, and disorders that could lead to OSCC with common etiological factors. Head and neck squamous cell carcinoma (SCC) remains a major cause of morbidity and … Oral squamous cell carcinoma (OSCC) is the eight most common cancer in the world.,, A recent trend seen in India is the increased incidence of OSCC in females without a deleterious habit history. Keywords: Would you like email updates of new search results? Careers. Abstract. Materials and Methods . Oral squamous cell carcinoma is predominately associated with tobacco and betel nut use. Exome Sequencing of Oral Squamous Cell Carcinoma Reveals Molecular Subgroups and Novel Therapeutic Opportunities. Jiang S, Dong Y. Curr Probl Cancer, 41(5):323-327, 01 Mar 2017 Cited by: 12 articles | PMID: 28416242. Review 2021 Jan 12;11(1):85. doi: 10.3390/biom11010085. Conclusion: Histopathological examination on biopsy tissue remains the gold standard for diagnosis. The treatment measures may include: In most cases, a wide surgical excision and removal of the entire tumor is the preferred treatment option. Oral squamous cell carcinoma (OSCC) is a pathological type of oral cancer, accounting for over 90% of oral cancers. Lindemann A, Takahashi H, Patel AA, Osman AA, Myers JN. Major risk factors include tobacco smoking and alcohol use [1]. Oral squamous cell carcinoma (OSCC) is a common malignancy of the head and neck region. Current Aspects on Oral Squamous Cell Carcinoma: Anastasios K Markopoulos: The Open Dentistry Journal. Despite several diagnostic and therapeutic advances over the last decades, the rate of mortality and 5-year survival of … “Recent Techniques for Diagnosis of Oral Squamous Cell Carcinoma”. 1, Jalan SS12/1A, Subang Jaya, Selangor, Malaysia. Abstract. 2012; | Oral squamous cell carcinoma (OSCC) is the leading cause of death in head and neck squamous cell carcinoma (HNSCC) with high malignancy, easy metastasis, and high recurrence. Drugs; Oral squamous cell carcinoma(OSCC); Progress; Targeted therapy. Introduction. Head and neck squamous cell carcinoma (HNSCC) accounted for more than 800 000 new cancers and 450 000 deaths in 2018 [].These cancers originate from the mucosa of the upper-aerodigestive track consisting of cancers of the larynx, hypopharynx, tonsil, oropharynx, and oral … In this study, we examined the roles of miR-146b in OSCC cells. Gatti V, Bernassola F, Talora C, Melino G, Peschiaroli A. 2018 Jun;97(6):635-644. doi: 10.1177/0022034518759068. A majority of these cancers are associated with lifestyle risk habits including smoking, excessive alcohol consumption and betel quid chewing. Clipboard, Search History, and several other advanced features are temporarily unavailable. 2021 Mar 18;14(6):101074. doi: 10.1016/j.tranon.2021.101074. … Several articles in the primary literature search evaluated recurrence and overall survival rates in relation to “head and neck cancer” or “squamous cell carcinoma” of the “upper aerodigestive tract”, including oral cavity, oropharynx, hypopharynx and larynx subsites. Oncotarget. Detection of OSCC is currently based on a thorough clinical oral examination combined with a biopsy for histological analysis. Inhibition of microRNA-15b-5p Attenuates the Progression of Oral Squamous Cell Carcinoma via Modulating the. eCollection 2020. Oral squamous cell carcinoma (OSCC) has a remarkable incidence over the world and a fairly strenuous prognosis, encouraging further research on the prognostic factors and new techniques for diagnosis that might modify disease outcome. Oral human papillomavirus (HPV), typically acquired via oral-genital contact, may have a role in the etiology of some oral cancers; however, HPV is identified in oral cancer much less often than it is in oropharyngeal cancer . Epub 2018 Jul 3. Jensen DH, Dabelsteen E, Specht L, Fiehn AM, Therkildsen MH, Jønson L, Vikesaa J, Nielsen FC, von Buchwald C. J Pathol. Oral squamous cell carcinoma (OSCC) has a striking global incidence and equally formidable mortality rates. 8600 Rockville Pike 6 The majority of patients with SCCOP have node-positive (cN+) necks at presentation, and 10% to 40% of … Privacy, Help As categorization was not always performed by the authors and results specifically dealing with OSCC were not either supported, these series were … Conventional oral squamous cell carcinoma (OSCC) is one of the most common cancers of the head and neck; the … Clipboard, Search History, and several other advanced features are temporarily unavailable. Pathology Location. 5 However, SCCOP has been increasing in incidence in recent decades as a result of chronic latent infection with the human papillomavirus and seems to disproportionately affect younger people. Objectives . Anti-tumor effect of carrimycin on oral squamous cell carcinoma cells in vitro and in vivo. Nowadays, recurrence in oral squamous cell carcinoma (OSCC) remains the main cause for failure in oral cancer patients, despite advances in surgical techniques and chemo-radiotherapy (CRT) protocols. Cancer Lett. Oral squamous cell carcinoma (OSCC) is a pathological type of oral cancer, accounting for over 90% of oral cancers 9. While survival rates have improved in recent years, new methods of treatment are being investigated to limit disease progression and to improve outcomes, particularly in oral cavity squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD). Oral squamous cell carcinoma (OSCC) is one of the most common human malignancies and endangers human health, and it accounts for 40% of all head and neck squamous cell carcinoma (HNSCC) cases (1,2). 2016 Jun;49(3):261-9. doi: 10.1111/cpr.12260. Recent advances of nano-drug delivery system in oral squamous cell carcinoma treatment 9447 no-carriers can easily pass through the vascular wall and reach the tumor tissue. FOIA Tongue squamous cell carcinoma (TSCC) is the most common carcinoma of OSCC, accounting for 25-40% of mouth neoplasms [1]. Oral squamous cell carcinoma (OSCC) is a major head and neck cancer and has negative effects on the quality of life and survival of patients. Oral cavity squamous cell carcinoma (OC‐SCC) is the most common malignancy of the head and neck (excluding nonmelanoma skin cancer). Oral squamous cell carcinomas (OSCC) are a heterogeneous group of cancers arising from the mucosal lining of the oral cavity. NCI CPTC Antibody Characterization Program. Background: Regional lymph node (LN) metastasis is the single most prognostic factor for oral squamous cell carcinoma (OSCC). 1 OSCC patients are considered different than those with other head and neck (H&N) cancers because of the intricate tri-dimensional anatomy of the mouth and proximity to vital structures. FOIA 23 , 287–291 (2017). Molecular targeted therapies in the management of head and neck squamous cell carcinoma: recent developments and perspectives. Published by Elsevier Ltd. National Library of Medicine Careers. 23 , 287–291 (2017). Squamous cell carcinoma (SCC) of the skin is a cancer of the cells that make up most of the top layer of normal skin. Oral squamous cell carcinoma is a cancer that affects the squamous cells of the oral cavity. The ventral surface of the tongue and the floor of the mouth are the sites most commonly affected by SCC be-cause they are lined by thin non-keratinised epithelium. Copyright © 2019. How is Squamous Cell Carcinoma of Oral Cavity Diagnosed? Keywords: Key words like “Oral squamous cell carcinoma”, “Oral cavity” “Diagnostic techniques” were used to search for articles. Vascular Endothelial Growth Factor: A Translational View in Oral Non-Communicable Diseases. 2016 May 10;7(19):27802-18. doi: 10.18632/oncotarget.8533. Oral squamous cell carcinoma (OSCC) is the leading cause of death in head and neck squamous cell carcinoma (HNSCC) with high malignancy, easy metastasis, and high recurrence. Onco Targets Ther. Semin Cancer Biol. Cancer Manag Res. Oral squamous cell carcinoma may present clinically as leukoplakia or as erythroplakia that in fact has already become malignant, as a necrotic ulcer with irregular raised indurated borders or as a broad-based exophytic mass with a … Bioinformatics Analyses Indicate That Cathepsin G (CTSG) is a Potential Immune-Related Biomarker in Oral Squamous Cell Carcinoma (OSCC). Of the two, squamous cell carcinoma is the second most prevalent but is potentially more devastating and life-threatening form of nonmelanoma skin cancer. Chai AWY(1), Lim KP(1), Cheong SC(2). Oral cancer is an aggressive malignant tumour that is prone to relapse and metastasis. The human oral squamous cell carcinoma cell lines CAL-27 and SCC-9 and the lentivirus vector packaging cell line HEK293t were obtained from the American Type Culture Collection (ATCC). Received: January 09, 2107; Published: January 27, 2017 Abstract Background: Oral squamous cell carcinoma comprises 90% of oral malignancies. 2, 3 The standardized treatment protocol for … In this paper, we discuss the research progress of targeted therapeutic drugs in the treatment of OSCC in recent years. This Research Topic aims at reporting the latest progress on genetic/epigenetic studies and omics studies for oral and esophageal squamous cell carcinoma. Squamous cell carcinoma (SCC) is the most common malignant neoplasm of the oral cavity and represents about 90% of all oral malignancies. Unable to load your collection due to an error, Unable to load your delegates due to an error. Staging. Cancers (Basel). (4)Department of Oral Pathology, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. head and neck squamous cell carcinoma, lingual abscess, oral cancer, submucosal squamous cell carcinoma, neoplasm presenting as abscess. Huang GZ, Wu QQ, Zheng ZN, Shao TR, Li F, Lu XY, Ye HY, Chen GX, Song YX, Zeng WS, Ai YL, Lv XZ. Cetuximab, targeting the epider … Translational genomics and recent advances in oral squamous cell carcinoma Semin Cancer Biol. Anticancer Agents Med Chem. Staging and grading of OSCC are established prerequisites for management, as they influence risk stratification and are the first step toward personalized treatment. The risk of developing this type of skin cancer is increased among fair-skinned and fair-haired people who have repeatedly been exposed to strong sunlight, individuals who had freckles as a child, and those with blue eyes. 13,14 One of the reasons for the poor prognosis of OSCC-patients is the inadequate therapeutic efficacy for complete OSCC destruction. Oral squamous cell carcinoma (OSCC) is the most common oral malignancy accounting for 94% of all malignant neoplasms of the oral cavity. Author information: (1)Head and Neck Cancer Research Team, Cancer Research Malaysia, No. 8600 Rockville Pike With over 200,000 newly diagnosed cases, it accounts for nearly one-third of all head and neck cancers [].Therapeutic approaches are primarily based on combination of surgery, radiotherapy, and chemotherapy, depending on site and stage [].Apart from the HPV status, biomarkers to predict the … Oral squamous cell carcinomas (OSCC) are a heterogeneous group of cancers arising from the mucosal lining of the oral cavity. about 50% of all cases of oral SCC [3,9]. More than 90% of them are squamous cell carcinoma, and the 5-year survival rate remains at about 50%-60%.The proposing of targeted therapy opens up a new way for the treatment of oral cancer and brings dawn to patients with advanced diseases. Hayes TF, Benaich N, Goldie SJ, Sipilä K, Ames-Draycott A, Cai W, Yin G, Watt FM. Human papillomavirus and oral squamous cell carcinoma: A review of HPV-positive oral squamous cell carcinoma and possible strategies for future. eCollection 2021. Life (Basel). 6 The majority of patients with SCCOP have node-positive (cN+) necks at presentation, and 10% to 40% of … Cell blocks were prepared for all samples and assessed for cytomorphology and immunocytochemistry of DNA mismatch repair proteins … Transl Oncol. A diagnosis of Squamous Cell Carcinoma of Oral Cavity is made by: Complete physical examination with detailed medical history evaluation; Examination by a dermatologist using a dermoscopy, a special device to examine the skin; Wood’s lamp examination: In this procedure, the healthcare provider examines the skin using … As GLOBOCAN reported in 2018, lung cancer was the first cause of … Cetuximab, targeting the epidermal growth factor receptor was approved for the treatment of OSCC in 2006, and remains the only molecular targeted therapy available for OSCC. In India, incidence rates for oral cavity cancers have increased in recent decade and over 1,000,000 new cases of oral squamous cell carcinoma (OSCC) are registered every year. Cancers of the oral cavity cause significant cancer-related death worldwide. It is estimated that between 17 and 35 percent of OSCCs arise from pre-existing leukoplakic lesions, while the remainder arise de novo from apparently normal oral epithelium . Studies in other languages and case reports were excluded. Bethesda, MD 20894, Copyright Targeting the DNA Damage Response in OSCC with TP53 Mutations. The present study aimed to investigate the cell cycle arrest, cytotoxic, and apoptotic effects of artichoke extract against the invasive oral squamous cell carcinoma. We aimed to identify new biomarkers or potential therapeutic targets for OSCC. Theranostics. There are three mechanisms of action of oral microbiota in cancer … Squamous cell carcinoma of the tongue may also result from any chronic irritation, such as dental caries, overuse of mouthwash, chewing tobacco, or the use of betel quid. 264 Oral Squamous Cell Carcinoma: Epidemiology, Clinical Presentation and Treatment . The role of novel prognostic markers PROX1 and FOXC2 in carcinogenesis of oral squamous cell carcinoma. Exome sequencing revealed that the significantly mutated genes are mainly tumour suppressors. Oral brush samples using Orcellex ® brushes were obtained from all participants directly before undergoing surgical biopsy. Fadlullah MZ, Chiang IK, Dionne KR, Yee PS, Gan CP, Sam KK, Tiong KH, Ng AK, Martin D, Lim KP, Kallarakkal TG, Mustafa WM, Lau SH, Abraham MT, Zain RB, Rahman ZA, Molinolo A, Patel V, Gutkind JS, Tan AC, Cheong SC. Squamous cell carcinoma sometimes develops from a precancerous skin growth called an actinic keratosis. It is a common type of oral cancer. Bethesda, MD 20894, Copyright Early diagnosis and treatment of Squamous Cell Carcinoma of Oral Cavity is important to avoid complications such as metastasis to other regions. Liang SY, Zhao TC, Zhou ZH, Ju WT, Liu Y, Tan YR, Zhu DW, Zhang ZY, Zhong LP. Liu X, Li Q, Huang P, Tong D, Wu H, Zhang F. J Cell Biochem. Oral Dis. 2021 Jan 1;17(2):430-447. doi: 10.7150/ijbs.54014. Seliger B, Massa C, Yang B, Bethmann D, Kappler M, Eckert AW, Wickenhauser C. Int J Mol Sci. J Dent Res. CiteScore: 6.0 ℹ CiteScore: 2019: 6.0 CiteScore measures the average citations received per peer-reviewed document published in this title. Cell Prolif. As per literature, squamous cell carcinomas of the alveolar ridge account for 9% of all the oral carcinomas. A majority of these cancers are associated with lifestyle risk habits including smoking, excessive alcohol consumption and betel quid chewing. Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm of the oral cavity. Over 75% of oral cavity squamous cell carcinomas occur in the lower lip, oral tongue, and floor of mouth 4. Translational genomics and recent advances in oral squamous cell carcinoma. 2021 Mar 14;19(1):75. doi: 10.1186/s12957-021-02184-8. OSCC accounts for 2-3% for all malignant tumors. This can be attributed to the fact that about two-thirds of persons with oral squamous cell carcinoma … Translational genomics and recent advances in oral squamous cell carcinoma. Integrative genomic and functional analysis of human oral squamous cell carcinoma cell lines reveals synergistic effects of FAT1 and CASP8 inactivation. Passive targeted drug delivery system mainly refers to the use of physical and chemical characteristics such as sur - face hydrophobicity or hydrophilicity of nanopar-ticles, electrostatic effect, magnetic force effect, … NCI CPTC Antibody Characterization Program. 13,14 One of the reasons for the poor prognosis of OSCC-patients is the inadequate therapeutic efficacy for complete OSCC destruction. CiteScore values are based on citation counts in a range of four years (e.g. PubMed Article PubMed Central Google Scholar Oral squamous cell carcinoma is the most common type of oral malignant neoplasm. This site needs JavaScript to work properly. Would you like email updates of new search results? J Exp Ther Oncol. Objectives: (1) To compare the value of various grading systems in predicting LN metastasis. Article Oral squamous cell carcinoma: Etiology, pathogenesis and prognostic value of genomic alterations Mehrotra R, Yadav S Department of Pathology, Moti Lal Nehru Medical College, University of Allahabad, 16/2, Lowther Road, Allahabad - 211002, India Correspondence to: Dr. Ravi Mehrotra, E-mail: mravi1@sancharnet.in Abstract The promising finding of checkpoint … 2013 Mar;13(3):389-402. Involvement of miR-619-5p in resistance to cisplatin by regulating ATXN3 in oral squamous cell carcinoma. doi: 10.7554/eLife.57761. EGFR-mediated signaling pathway influences the sensitivity of oral squamous cell carcinoma to JQ1. Oral squamous cell carcinoma (OSCC) is a major head and neck cancer and has negative effects on the quality of life and survival of patients. Circ-KIAA0907 inhibits the progression of oral squamous cell carcinoma by regulating the miR-96-5p/UNC13C axis. A … An update on the latest evidence for managing the clinically negative neck (cN0) in oral squamous cell carcinoma. Most cases of OSCC are not detected until the cancer has developed into advanced stages; thus, a reliable early-stage diagnostic marker is needed.

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