prognostic markers for oral squamous cell carcinoma

prognostic markers for oral squamous cell carcinoma

Elective Neck Dissection vs Observation in Early-Stage Squamous Cell Carcinoma of the Oral Tongue With No Clinically Apparent Lymph Node Metastasis in the Neck: A Systematic Review and Meta-analysis. Front Public Health. GLUT1 and GLUT3 protein expression evaluated by immunohistochemistry are, significantly, indicators of poor prognosis outcome in oral squamous cell carcinoma, probably due to the enhanced glycolytic metabolism of more aggressive neoplastic cells. 2015;2015:186904. doi: 10.1155/2015/186904. Survival Significance of Number of Positive Lymph Nodes in Oral Squamous Cell Carcinoma Stratified by p16. Limitations in the quality of the published studies (e.g., small cohorts, lack of compliance with REMARK guidelines) are widespread. 2018 Feb 20;118(4):577-586. doi: 10.1038/bjc.2017.425. 2011 Apr 26;104(9):1440-51. doi: 10.1038/bjc.2011.110. doi: 10.1038/bjc.2017.482. Prognostic significance of molecular markers in oral squamous cell carcinoma: a multivariate analysis Head Neck , 31 ( 2009 ) , pp. Aiming to increase survival rate, recent research has underlined the significance of harnessing the immune response in treatment of many cancers. 2021 Feb 12;57(2):164. doi: 10.3390/medicina57020164. Hadler-Olsen, E., Wirsing, A.M. Tissue-infiltrating immune cells as prognostic markers in oral squamous cell carcinoma: a systematic review and meta-analysis. 15 , 2277–2286 (2019). -, Almangush A, Bello IO, Coletta RD, Makitie AA, Makinen LK, Kauppila JH, Pukkila M, Hagstrom J, Laranne J, Soini Y, Kosma VM, Koivunen P, Kelner N, Kowalski LP, Grenman R, Leivo I, Läärä E, Salo T (2015) For early-stage oral tongue cancer, depth of invasion and worst pattern of invasion are the strongest pathological predictors for locoregional recurrence and mortality. Biomarkers for Immunotherapy of Oral Squamous Cell Carcinoma: Current Status and Challenges. For studies of VEGF A and C the results were equivocal, but the pooled analysis of VEGF A separately showed it to be a useful prognosticator for OTSCC. Introduction. The five biomarkers most frequently assessed were p53, Ki-67, p16, VEGFs and cyclin D1. Methods Quantitative polymerase chain reactions (qPCRs) were utilized to detect the NOS2 levels in fresh‐frozen tissue samples of NOM (n = 6), OL (n = 20), and OSCC (n = 15). Copyright © 2017 Elsevier Ltd. All rights reserved. The major prognostic factors are stage at the time of diagnosis, unexpected close margins at resection, depth and pattern of tissue invasion by carcinoma and extracapsular spread. Epub 2011 Mar 29. Routray S, Kumar R, Datta KK, Puttamallesh VN, Chatterjee A, Gowda H, Mohanty N, Dash R, Dixit A. Sci Rep. 2021 Mar 18;11(1):6208. doi: 10.1038/s41598-021-85729-x. Oral Oncol 48(12): 1263–1271. National Library of Medicine 2019 Apr;120(7):714-727. doi: 10.1038/s41416-019-0409-6. We investigate hnRNP K, TP and FLIP expression and assess the prognostic and therapeutic potential of these markers in oral squamous cell carcinoma (OSCC). Glut1 and Glut3 as Potential Prognostic Markers for Oral Squamous Cell Carcinoma Fernanda Rocha Rojas Ayala , 1 Rafael Malagoli Rocha , 1, * Kátia Cândido Carvalho , 1 André Lopes Carvalho , 2, 3 Isabela Werneck da Cunha , 1 Silvia Vanessa Lourenço , 4 and Fernando Augusto Soares 1 doi: 10.1038/bjc.2017.491. Oral squamous cell carcinoma (OSCC), the most common type of head and neck cancers, is associated with high recurrence, metastasis, low long-term … An integrated approach for identification of a panel of candidate genes arbitrated for invasion and metastasis in oral squamous cell carcinoma. Lu JW, Tseng YS, Lo YS, Lin YM, Yeh CM, Lin SH. Epub 2018 Mar 13. Wang SR, Sun W, Zhou N, Zhao K, Li WJ, Chi ZP, Wang Y, Wang QM, Tong L, He ZX, Han HY, Chen ZG. Min A, Zhu C, Peng S, Rajthala S, Costea DE, Sapkota D. Biomed Res Int. Would you like email updates of new search results? Therefore, the aim of the present study was to evaluate the prognostic impact of eight miRNAs connected to oral squamous cell carcinoma (OSCC). Clipboard, Search History, and several other advanced features are temporarily unavailable. All studies which had investigated the prognostic significance of immunohistochemical biomarkers in OTSCC during the period from 1985 to 2015 were retrieved. 2019 Dec;36(6):481-492. doi: 10.1007/s10585-019-09994-x. 2019 Oct;41(10):3499-3515. doi: 10.1002/hed.25866. Epub 2018 Feb 15. Over the years, several tumor biomarkers have been suggested to foresee the prognosis oral squamous cell carcinoma (OSCC) patients. Privacy, Help Front Oncol. Here, we summarise existing evidence regarding immunohistochemical prognostic biomarkers for OTSCC. Preoperative high c-reactive protein/albumin ratio is a poor prognostic factor of oral squamous cell carcinoma. NCI CPTC Antibody Characterization Program, Adduri R Sr, Kotapalli V, Gupta NA, Gowrishankar S, Srinivasulu M, Ali MM, Rao S, Uppin SG, Nayak UK, Dhagam S, Chigurupati MV, Bashyam MD (2014) P53 nuclear stabilization is associated with FHIT loss and younger age of onset in squamous cell carcinoma of oral tongue. Prognostic Significance of Cytoplasmic SPNS2 Expression in Patients with Oral Squamous Cell Carcinoma. Kiyosue T, Kawano S, Matsubara R, Goto Y, Hirano M, Jinno T, Toyoshima T, Kitamura R, Oobu K, Nakamura S. Int J Clin Oncol. Epub 2015 Oct 4. Immunohistochemistry panels are used to evaluate proliferation, vascularization, apoptosis, HPV infection, and keratin expression, which are important markers of malignant progression. Gynecol Oncol. Over 260,000 (2013) new oral squamous cell carcinoma (OSCC) cases are reported annually worldwide. -. Clipboard, Search History, and several other advanced features are temporarily unavailable. 2021 Feb 1;39(1):64-73. doi: 10.7518/hxkq.2021.01.010. Accessibility National Library of Medicine Wang, Q. et al. This site needs JavaScript to work properly. Here, we present a systematic review to identify, evaluate and summarize the evidence for OSCC reported markers. Sci Rep. 2021 Mar 25;11(1):6939. doi: 10.1038/s41598-021-86208-z. Meta-analysis of immunohistochemical prognostic markers in resected pancreatic cancer. Head Neck. Silva Servato JP(1), Ueira Vieira C(2), de Faria PR(3), Cardoso SV(4), Loyola AM(4). Oral squamous cell carcinoma (OSCC) is the major cancer of head and neck with increasing incidence and mortality in Taiwan. Troiano G, Mastrangelo F, Caponio VCA, Laino L, Cirillo N, Lo Muzio L. J Dent Res. 2021 Mar 8;11:616629. doi: 10.3389/fonc.2021.616629. 2019 Jan;152(1):208-217. doi: 10.1016/j.ygyno.2018.10.015. See this image and copyright information in PMC. Immunohistochemical location of the p75 neurotrophin receptor (p75NTR) in oral leukoplakia and oral squamous cell carcinoma. Br J Cancer (2019) 120:714–27. Medicina (Kaunas). Eligible studies were identified through a literature s … Front Oncol. Eligible studies were identified through a literature search of MEDLINE/PubMed until January 2016. Tumour budding in oral squamous cell carcinoma: a meta-analysis. Tumorous and adjacent tissues were collected from three … Prevention and treatment information (HHS). Despite development in OSCC management, the outcome is still unsatisfactory. Further research is required to validate these biomarkers in well-designed clinical cohort-based studies. In this study, we identify the levels of iNOS and nitrotyrosine in the sample of normal oral mucosa (NOM), oral leukoplakia (OL), and oral squamous cell carcinoma (OSCC). Background: -, Albert S, Hourseau M, Halimi C, Serova M, Descatoire V, Barry B, Couvelard A, Riveiro ME, Tijeras-Raballand A, de Gramont A, Raymond E, Faivre S (2012) Prognostic value of the chemokine receptor CXCR4 and epithelial-to-mesenchymal transition in patients with squamous cell carcinoma of the mobile tongue. Careers. 2016 Sep 1;142(9):857-65. doi: 10.1001/jamaoto.2016.1281. Oral squamous cell carcinoma (OSCC) is a major type of head and neck cancer, accounting for ~2%–4% of all incident cancer cases per year. Prevention and treatment information (HHS). Methods: FOIA Would you like email updates of new search results? 1. A total of 174 studies conducted during the last three decades were found, and in these 184 biomarkers were evaluated for the prognostication of OTSCC. The selected studies are of good quality, although, any study referred to a sample size determination. The objective of the study was to examine the prognostic value of hypoxia-inducible factor-1α (HIF-1α), carbonic anhydrase-IX (CA-IX), cyclooxygenase-2 (COX-2), Ki-67, and erythropoietin receptor in patients with oral tongue squamous cell carcinoma. Keywords: Epub 2017 Nov 30. Tissue-infiltrating immune cells as prognostic markers in oral squamous cell carcinoma: a systematic review and meta-analysis Br J Cancer . eCollection 2021. As the morbidity and mortality of the disease have increased year by year, the search for a promising diagnostic and prognostic biomarker for the disease is becoming increasingly urgent. Considering the lack of follow-up studies, the molecules are still potential biomarkers. There was no sufficient evidence to support p53, Ki-67 and p16 as prognostic biomarkers for OTSCC. Routray S, Kumar R, Datta KK, Puttamallesh VN, Chatterjee A, Gowda H, Mohanty N, Dash R, Dixit A. Sci Rep. 2021 Mar 18;11(1):6208. doi: 10.1038/s41598-021-85729-x. MicroRNAs as Important Players and Biomarkers in Oral Carcinogenesis. Careers. Identification of inflammatory mediators associated with metastasis of oral squamous cell carcinoma in experimental and clinical studies: systematic review. Peer J 8:e9393 DOI 10.7717/peerj.9393 Numerous biomarkers have been presented as useful prognosticators for OTSCC, but the quality of the conduct and reporting of original studies is overall unsatisfactory which does not allow reliable conclusions. Privacy, Help Here, we summarise existing evidence regarding immunohistochemical prognostic biomarkers for OTSCC. 1. Braz Oral Res. 2021 Feb 3;9:631118. doi: 10.3389/fpubh.2021.631118. Importance of the PD-1/PD-L1 Axis for Malignant Transformation and Risk Assessment of Oral Leukoplakia. Barnabé LÉG, Batista AC, Mendonça EF, Nonaka CFW, Alves PM. For several decades the management of OSCC consisted of surgery with or without radiotherapy or chemoradiotherapy. 2018 Mar 6;118(5):e11. Immunohistochemical analysis of marker expression was performed on tissue samples from 25 patients with tongue squamous cell carcinoma. Elhousiny M, Miller K, Ariyawadana A, Nimmo A. Clin Exp Metastasis. Zedan W(1), Mourad MI(2), El-Aziz SM(3), Salamaa NM(4), Shalaby AA(5). Epub 2018 Nov 8. CAS Article Google Scholar -, Altman DG, McShane LM, Sauerbrei W, Taube SE (2012. b) Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK): explanation and elaboration. Si Q, Ye Q, Bing Z, Fan R, Hu X, Liu B, Wang J, Liu Y, An X. 2019 Nov 25;33:e103. Li P, Fang Q, Yang Y, Chen D, Du W, Liu F, Luo R. Front Oncol. We examined the usefulness of the prognostic nutritional index (PNI) as a prognostic tool in patients with oral squamous cell carcinoma who underwent radical surgery. 1. Bethesda, MD 20894, Copyright Tissue-infiltrating immune cells as prognostic markers in oral squamous cell carcinoma: a systematic review and meta-analysis. BMC Med 10: 51. 2021 Feb 16;9(2):194. doi: 10.3390/biomedicines9020194. The authors declare no conflict of interest. Cyclin D1 and p16INK4A expression predict reduced survival in carcinoma of the anterior tongue. Results: Here, we present a systematic review to identify, evaluate and summarize the evidence for OSCC reported markers. Unable to load your collection due to an error, Unable to load your delegates due to an error. -, Altman DG, McShane LM, Sauerbrei W, Taube SE (2012. a) Reporting recommendations for tumor marker prognostic studies (REMARK): explanation and elaboration. Please enable it to take advantage of the complete set of features! Background: Identifying informative prognostic biomarkers for oral tongue squamous cell carcinoma (OTSCC) is of great importance in order to better predict tumour behaviour and to guide treatment planning. MicroRNA expression patterns in oral squamous cell carcinoma: hsa‐mir‐99b‐3p and hsa‐mir‐100‐5p as novel prognostic markers for oral cancer. We found 41 biomarkers, mostly proteins evaluated by immunohistochemistry. 2021 Mar 8;11:616629. doi: 10.3389/fonc.2021.616629. Here, we present a systematic review to identify, evaluate and summarize the evidence for OSCC reported markers. The overall 5-year survival rate following treatment for oral squamous cell carcinoma is around 50% in most published series. Ries J, Agaimy A, Wehrhan F, Baran C, Bolze S, Danzer E, Frey S, Jantsch J, Möst T, Büttner-Herold M, Wickenhauser C, Kesting M, Weber M. Biomedicines. Five-year survival rates for oral squamous cell carcinoma (OSCC) are 30% and the mortality rate is 50%. Epub 2019 Sep 26. J Oral Pathol Med. FOIA In the meta-analyses, the most promising results of the prognostic power for OTSCC were obtained for cyclin D1. eCollection 2021. BMC Clin Pathol 14: 37. 2019 Aug 4. doi: 10.1111/jop.12942. SPINK7 expression changes accompanied by HER2, P53 and RB1 can be relevant in predicting oral squamous cell carcinoma at a molecular level. Reply to 'Comment on 'Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis". Future Oncol. Comment on 'Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis'. Eligible studies were identified through a literature search of MEDLINE/PubMed until January 2016. as a novel diagnostic/prognostic biomarker for oral squamous cell carcinoma via RNA sequencing and bioinformatic analyses. An integrated approach for identification of a panel of candidate genes arbitrated for invasion and metastasis in oral squamous cell carcinoma. 2018 Mar 6;118(5):e12. Epub 2019 Jul 29. Identifying informative prognostic biomarkers for oral tongue squamous cell carcinoma (OTSCC) is of great importance in order to better predict tumour behaviour and … eCollection 2019. PLoS Med 9(5): e1001216. Oral squamous cell carcinoma (OSCC) is one of the most common types of malignancies worldwide, and its morbidity and mortality have increased in the near term. Bova RJ, Quinn DI, Nankervis JS, Cole IE, Sheridan BF, Jensen MJ, Morgan GJ, Hughes CJ, Sutherland RL. We included primary articlesreporting overall survival, disease-free survival and cause-specific survival as outcomes. 2019 Apr;120(7):714-727. doi: 10.1038/s41416-019-0409-6. 2021 Mar 4;11:545433. doi: 10.3389/fonc.2021.545433. Biomarkers for Immunotherapy of Oral Squamous Cell Carcinoma: Current Status and Challenges. Tissue-infiltrating immune cells as prognostic markers in oral squamous cell carcinoma: a … 8600 Rockville Pike Predictive Prognostic Value of Tissue-Based MicroRNA Expression in Oral Squamous Cell Carcinoma: A Systematic Review and Meta-analysis. The value of two biomarkers (VEGF-A and cyclin D1) should be validated in a multicentre study setting following REMARK guidelines. Sand FL, Nielsen DMB, Frederiksen MH, Rasmussen CL, Kjaer SK. The prognostic value of p16 and p53 expression for survival after vulvar cancer: A systematic review and meta-analysis. A systematic search of the literature was performed using the databases of Scopus, Ovid Medline, Web of Science and Cochrane Library. Cytogenetic significance of chromosome 17 aberrations and P53 gene mutations as prognostic markers in oral squamous cell carcinoma. Effects of isoprenylcysteine carboxyl methyltransferase silencing on the proliferation and apoptosis of tongue squamous cell carcinoma. JAMA Otolaryngol Head Neck Surg. COVID-19 is an emerging, rapidly evolving situation. 2018 Jul;97(7):759-766. doi: 10.1177/0022034518762090. Epub 2019 Feb 27. Carbon Ion Irradiation Enhances the Anti-tumor Efficiency in Tongue Squamous Cell Carcinoma via Modulating the FAK Signaling.

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